Postdoctoral Fellow - Subramaniam Lab
Florida Atlantic University

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Position Summary:

We are seeking a highly motivated postdoctoral candidate with a PhD in cellular and molecular biology, with a strong understanding of biological processes using cell and animal models. The ideal candidate will have a background in neuroscience or closely-related disciplines, with a particular focus on neurodegenerative diseases such as Alzheimer's, Huntington's, or Parkinson's disease.

Dr. Subramaniam's lab uses cell and animal models combined with cellular, molecular, signaling and system biology approaches to investigate neurodegenerative disease mechanisms. The SNBI-FAU comprises distinguished faculties, cutting-edge facilities, and is situated on campus, encompassing the Max Planck Institute and the UF-Scripps Research Institute, which provide exceptional opportunities for academic and collaborative studies. Jupiter, Florida, USA, has a population of ~62,000 and is located in Palm Beach County, which is considered one of the nicest places to live in Florida. Jupiter has many restaurants, coffee shops, parks, and wonderful beaches. Jupiter's public schools receive excellent ratings.

Key Responsibilities:

• Conduct independent research on cellular and molecular mechanisms underlying neurodegenerative diseases.
• Utilize cell and animal models to investigate disease pathology and potential therapeutic interventions.
• Perform advanced techniques including mouse handling, stereotaxic surgery, and brain imaging analysis.
• Analyze and interpret complex data, and present findings in peer-reviewed publications and at scientific conferences.
• Collaborate with a multidisciplinary team of researchers and contribute to ongoing projects.
• Mentor and supervise graduate students and research assistants.

Please review the following examples of publications.

1. Subramaniam S, Sixt KM, Barrow R, Snyder SH. Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity. Science. 2009; PMID: 19498170.

2. Pryor WM, Biagioli M, Shahani N, Swarnkar S, Huang WC, Page DT, MacDonald ME, Subramaniam S. Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington's disease. Science Signaling. 2014. PMID: 25351248.

3. Shahani N, Swarnkar S, Giovinazzo V, Morgenweck J, Bohn LM, Scharager-Tapia C, Pascal B, Martinez-Acedo P, Khare K, Subramaniam S. RasGRP1 promotes amphetamine-induced motor behavior through a Rhes interaction network ("Rhesactome") in the striatum. Science Signaling. 2016. PMID: 27902448; PMCID: PMC5142824.

4. Sharma M, Jarquin UNR, Rivera O, Kazantzis M, Eshraghi M, Shahani N, Sharma V, Tapia R, Subramaniam S. Rhes, a striatal-enriched protein, promotes mitophagy via Nix. Proc Natl Acad Sci U S A. 2019; PMID: 31676548.

5. Eshraghi M, Ramirez-Jarquin UN, Shahani N, Nuzzo T, De Rosa A, Swarnkar S, Galli N, Rivera O, Tsaprailis G, Scharager-Tapia C, Crynen G, Li Q, Thiolat ML, Bezard E, Usiello A, Subramaniam S. RasGRP1 is a causal factor in the development of l-DOPA-induced dyskinesia in Parkinson's disease. Science Advances. 2020; PMID: 32426479.

6. Eshraghi M, Karunadharma PP, Blin J, Shahani N, Ricci EP, Michel A, Urban NT, Galli N, Sharma M, Ramirez-Jarquin UN, Florescu K, Hernandez J, Subramaniam S. Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease. Nature Communications. 2021; PMID: 33674575.

7. Ramirez-Jarquin UN, Sharma M, Shahani N, Li Y, Boregowda S, Subramaniam S. Rhes protein transits from neuron to neuron and facilitates mutant huntingtin spreading in the brain. Science Advances. 2022; PMID: 35319973.

8. Ramirez-Jarquin UN, Sharma M, Zhou W, Shahani N, Subramaniam S. Deletion of SUMO1 attenuates behavioral and anatomical deficits by regulating autophagic activities in Huntington disease. Proc Natl Acad Sci U S A. 2022; PMID: 35086928.

9. Rivera O, Sharma M, Dagar S, Shahani N, Ramlrez-Jarquln UN, Crynen G, Karunadharma P, McManus F, Bonneil E, Pierre T, Subramaniam S. Rhes, a striatal enriched protein, regulates post-translational small-ubiquitin-like-modifier (SUMO) modification of nuclear proteins and alters gene expression. Cell Mol Life Sci. 2024; PMID: 38589732.

10. Dagar S, Sharma M, Tsaprailis G, Tapia CS, Crynen G, Joshi PS, Shahani N, Subramaniam S. Ribosome Profiling and Mass Spectrometry Reveal Widespread Mitochondrial Translation Defects in a Striatal Cell Model of Huntington Disease. Mol Cell Proteomics. 2024; PMID: 38447791.

Regarding previous work of Dr. Subramaniam's lab, please visit https://www.ncbi.nlm.nih.gov/myncbi/srinivasa.subramaniam.1/bibliography/public/

The College of Science at Florida Atlantic University seeks scholars who are committed to supporting the learning needs of students from diverse backgrounds and to thoughtfully engaging all communities in higher education. Florida Atlantic University embodies a culture of strategic and collaborative community engagement that results in mutual benefit to the institution and the various internal and external communities that it serves.

Minimum Qualifications:A postdoc candidate should have a PhD in cellular and molecular understanding of the biological process using cell and animal model. Neuroscience or closely-related disciplines with particular focus on neurodegenerative disease such as Alzheimer, Huntington, or Parkinson is a plus. The candidate should have demonstrated ability of research work through peer-reviewed publications. Postdoc applicants with experience in mouse handling, stereotaxic surgery, and brain imaging analysis are given priority.Salary:Commensurate with ExperienceCollege or Department:College of ScienceLocation:John D. MacArthur Campus - JupiterWork Days and Hours:N/AApplication Deadline: 2026-01-01Special Instructions to Applicant: This position is open until filled and may close without prior notice.

This position is subject to funding.

All applicants must apply electronically to the currently posted position on the Office of Human Resources' job website (https://fau.edu/jobs) by completing the required employment application for this recruitment and submitting the related documents.

Required Documents:
FAU's Career Page permits the attachment of required/requested documentation.

PLEASE NOTE: A maximum of five (5) documents may be attached to your application. If more than five (5) documents are required for submission, please combine additional documents into a single attachment to not exceed the maximum permitted.

The site permits the attachment of required/requested documentation. When completing the online application, please upload the following: a cover letter, curriculum vitae, and three letters of recommendation.

Transcripts:
Final candidate will be required to have official, sealed transcripts and original NACES evaluation, if applicable, sent from their educational institution to Human Resources prior to the start of employment.

Background Screening:
Selected candidates must successfully complete and pass all employment screenings prior to the start of employment. Employment screenings may include a criminal background check (level I and level II), motor vehicle check, credit check, reference checks, alcohol, and drug screening check.

Accommodations:
Individuals requiring accommodation, please call 561-297-3057. 711

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